FEATURES

FAMILY

DESCRIPTION

Also known as FOLR1_HUMAN, FOLR1, FOLR. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FOLR1

Mutations

Mutation(s) distribution

Mutations table