FEATURES

FAMILY

DESCRIPTION

Also known as RPA1_SCHPO, rpa1, nuc1. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.

EXTERNAL LINKS

rpa1

Mutations

Mutation(s) distribution

Mutations table