FEATURES

FAMILY

DESCRIPTION

Also known as PGCA_HUMAN, ACAN, AGC1, CSPG1, MSK16. This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. Interacts with FBLN1 (By similarity). Interacts with COMP.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ACAN

Aggrecan core protein

ACAN

Molecular Synopsis