FEATURES

DESCRIPTION

Also known as CTLA4_HUMAN, CTLA4, CD152. Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Homodimer; disulfide-linked (PubMed:11279501, PubMed:11279502, Ref.23, PubMed:21156796, PubMed:28484017). Binds to CD80/B7-1 and CD86/B7.2 (PubMed:11279501, PubMed:11279502, PubMed:28484017). Interacts with ICOSLG (PubMed:28484017).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CTLA4

Cytotoxic T-lymphocyte protein 4

CTLA4

Molecular Synopsis