FEATURES

FAMILY

DESCRIPTION

Also known as PRLR_HUMAN, PRLR. This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PRLR

Mutations

Mutation(s) distribution

Mutations table