FEATURES

FAMILY

DESCRIPTION

Also known as ITA2_HUMAN, ITGA2, CD49B. Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix., (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A., (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8. Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.

Also known as ITA2_HUMAN, ITGA2, CD49B. Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated seq ...

EXTERNAL LINKS

ITGA2

Mutations

Mutation(s) distribution

Mutations table