FEATURES

FAMILY

DESCRIPTION

Also known as TYRP1_HUMAN, TYRP1, CAS2, TYRP, TYRRP. Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458). Catalyzes the oxidation of 5, 6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5, 6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+) (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). Monomer (PubMed:28661582). Interacts with ATP7A (By similarity).

Also known as TYRP1_HUMAN, TYRP1, CAS2, TYRP, TYRRP. Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458). Catalyzes the oxidation of 5, 6-dihydroxyindole-2-carboxylic acid (DH ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TYRP1

Mutations

Mutation(s) distribution

Mutations table