FEATURES

FAMILY

DESCRIPTION

Also known as CAN2_HUMAN, CAPN2, CANPL2. Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Interacts with CPEB3; this leads to cleavage of CPEB3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CAPN2

Calpain-2 catalytic subunit

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

CAPN2

Structural Ligandability

Domains Chains

Distribution