FEATURES

FAMILY

DESCRIPTION

Also known as TCPA_HUMAN, TCP1, CCT1, CCTA. Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:1630492, PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with GBA (PubMed:21098288). Interacts with DLEC1 (PubMed:33144677).

EXTERNAL LINKS

TCP1

T-complex protein 1 subunit alpha

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

TCP1

Structural Ligandability

Domains Chains

Distribution