FEATURES

DESCRIPTION

Also known as IL1RA_HUMAN, IL1RN, IL1F3, IL1RA. Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IL1RN

Interleukin-1 receptor antagonist protein

IL1RN

Molecular Synopsis