FEATURES

FAMILY

class-IV pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as DAAA_BACYM, dat. Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. The second-half reaction is the reverse of the first, transferring the amino group from the pyridoxamine to a second alpha-keto acid to form the product D-amino acid via a ping-pong mechanism. This is an important process in the formation of D-alanine and D-glutamate, which are essential bacterial cell wall components. Homodimer.

Also known as DAAA_BACYM, dat. Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-am ...

EXTERNAL LINKS

dat

Mutations

Mutation(s) distribution

Mutations table