FEATURES

DESCRIPTION

Also known as ISK2_HUMAN, SPINK2. As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SPINK2

Serine protease inhibitor Kazal-type 2

Mutations

Mutation(s) distribution

Mutations table

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