FEATURES

FAMILY

DESCRIPTION

Also known as AL5AP_HUMAN, ALOX5AP, FLAP. Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Homotrimer. Interacts with LTC4S and ALOX5.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ALOX5AP

Arachidonate 5-lipoxygenase-activating protein

Mutations

Mutation(s) distribution

Mutations table

Search Mutation