FEATURES

FAMILY

eukaryotic-type primase large subunit family

DESCRIPTION

Also known as PRI2_YEAST, PRI2. DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48. DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Interacts with MCM10.

EXTERNAL LINKS

uniprot
enzyme classification

PRI2

DNA primase large subunit

PRI2

Molecular Synopsis