FEATURES

FAMILY

DESCRIPTION

Also known as CP2B6_HUMAN, CYP2B6. A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed:21289075, PubMed:12865317). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8, 9-, 11, 12-, and 14, 15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed:21289075, PubMed:12865317). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed:11695850, PubMed:22909231). Acts as a 1, 4-cineole 2-exo-monooxygenase (PubMed:11695850)., Allele 2B6*9: Has low affinity for anandamide and can only produce 11, 12 EpETrE-EAs.

EXTERNAL LINKS

CYP2B6

Mutations

Mutation(s) distribution

Mutations table