FEATURES

FAMILY

DESCRIPTION

Also known as HNF1A_HUMAN, HNF1A, TCF1. Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:12453420, PubMed:10966642). Activates the transcription of CYP1A2, CYP2E1 and CYP3A11 (By similarity). Binds DNA as a dimer (PubMed:12453420). Heterotetramer with PCBD1; formed by a dimer of dimers (By similarity). Interacts with PCBD1 (PubMed:10966642). Interacts with BHLHE41 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HNF1A

Hepatocyte nuclear factor 1-alpha

HNF1A

Molecular Synopsis