FEATURES

FAMILY

DESCRIPTION

Also known as IMDH1_HUMAN, IMPDH1, IMPD1. Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IMPDH1

Inosine-5'-monophosphate dehydrogenase 1

IMPDH1

Molecular Synopsis