FEATURES

FAMILY

DESCRIPTION

Also known as ARBK1_BOVIN, GRK2, ADRBK1. Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity). Key regulator of LPAR1 signaling (By similarity). Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity). Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (PubMed:21659505). Inhibits relaxation of airway smooth muscle in response to blue light (By similarity). Interacts with the heterodimer formed by GNB1 and GNG2 (PubMed:12764189). Interacts with GIT1 (PubMed:9826657). Interacts with, and phosphorylates chemokine-stimulated CCR5 (By similarity). Interacts with ARRB1 (By similarity). Interacts with LPAR1 and LPAR2 (By similarity). Interacts with RALA in response to LPAR1 activation (By similarity). ADRBK1 and RALA mutually inhibit each other's binding to LPAR1 (By similarity). Interacts with ADRB2 (By similarity).

EXTERNAL LINKS

GRK2

Beta-adrenergic receptor kinase 1

GRK2

Molecular Synopsis