FEATURES

FAMILY

phlebovirus envelope glycoprotein family

DESCRIPTION

Also known as GP_RVFVZ, GP. Structural component of the virion that interacts with glycoprotein N. About 720 Gn and 720 Gc proteins form 12 pentameric and 110 hexameric capsomeres. Theses capsomeres are arranged on the virus envelop surface in an icosahedral lattice with a T=12 quasisymmetry. Attaches the virion to a cell receptor and thereby promotes fusion after endocytosis of the virion. Contains a Golgi retention signal on its C-terminal region and brings Gc to the host Golgi apparatus where assembly occurs., Structural component of the virion that interacts with glycoprotein C. About 720 Gn and 720 Gc proteins form 12 pentameric and 110 hexameric capsomeres. Theses capsomeres are arranged on the virus envelop surface in an icosahedral lattice with a T=12 quasisymmetry. Attaches the virion to a cell receptor and thereby promotes fusion after endocytosis of the virion., Plays a role in the inhibition of virus-induced apoptosis. Plays a role for virus dissemination in vertebrates., Plays a role for virus dissemination in mosquitoes. May act as a structural virion protein in insects. Glycoprotein C and Glycoprotein N interact with each other. Glycoprotein Gn interacts with nucleocapsid protein N and with the polymerase L in order to package them into virus particles.

EXTERNAL LINKS

GP

Structural Ligandability

Domains Chains

Distribution