FEATURES

FAMILY

DESCRIPTION

Also known as MDR1A_MOUSE, Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3. Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (By similarity). Interacts with PSMB5.

Also known as MDR1A_MOUSE, Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3. Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exop ...

EXTERNAL LINKS

uniprot
enzyme classification

Abcb1a

Mutations

Mutation(s) distribution

Mutations table