FEATURES

FAMILY

DESCRIPTION

Also known as LPXD_ECOLI, lpxD, firA, omsA. Catalyzes the N-acylation of UDP-3-O-(hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers (3R)-3-hydroxytetradecanoyl-ACP over (3R)-3-hydroxyhexadecanoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxytetradecanoate at the 2 and 2' positions. Homotrimer.

EXTERNAL LINKS

uniprot
enzyme classification

lpxD

UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

lpxD

Molecular Synopsis