FEATURES

FAMILY

DESCRIPTION

Also known as DPOE_YEAST, POL2, DUN2. Catalytic component of the DNA polymerase epsilon complex which participates in chromosomal DNA replication (PubMed:1537345). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (PubMed:31488849). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (PubMed:12124389). DNA polymerase epsilon is a heterotetramer consisting of POL2, DPB2, DPB3 and DPB4.

EXTERNAL LINKS

uniprot
enzyme classification

POL2

DNA polymerase epsilon catalytic subunit A

Mutations

Mutation(s) distribution

Mutations table

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