FEATURES

FAMILY

DESCRIPTION

Also known as UBA1_YEAST, UBA1. Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Monomer. Binds simultaneously two ubiquitin chains.

EXTERNAL LINKS

uniprot
enzyme classification

UBA1

Ubiquitin-activating enzyme E1 1

UBA1

Molecular Synopsis