FEATURES

DESCRIPTION

Also known as HAP40_HUMAN, F8A1, F8A2, F8A3. RAB5A effector molecule that is involved in vesicular trafficking of early endosomes (PubMed:16476778). Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778). Interacts with HTT (via C-terminus) (PubMed:29466333). Interacts with RAB5A (By similarity). Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

F8A1, F8A2, F8A3

40-kDa huntingtin-associated protein

F8A1, F8A2, F8A3

Molecular Synopsis