FEATURES

FAMILY

Small multidrug resistance (SMR) (TC 2.A.7.1) family

DESCRIPTION

Also known as EMRE_ECOLI, emrE, eb, mvrC. Multidrug efflux protein that confers resistance to a wide range of toxic compounds, including ethidium, methyl viologen, acriflavine, tetraphenylphosphonium (TPP(+)), benzalkonium, propidium, dequalinium and the aminoglycoside antibiotics streptomycin and tobramycin (PubMed:7896833, PubMed:9050242, PubMed:10681497, PubMed:11574548, PubMed:15371426, PubMed:18024586, PubMed:18295794, PubMed:23042996, PubMed:24448799). Can also transport the osmoprotectants betaine and choline (PubMed:22942246). The drug efflux is coupled to an influx of protons (PubMed:7896833, PubMed:15371426, PubMed:29114048). Can couple antiport of a drug to either one or two protons, performing both electrogenic and electroneutral transport of a single substrate (PubMed:29114048). Simultaneously binds and cotransports proton and drug (PubMed:29114048, PubMed:30287687). Homodimer (PubMed:14633977, PubMed:15111102, PubMed:14755055, PubMed:15882076, PubMed:17003034, PubMed:18024586, PubMed:20551331, PubMed:22178925, PubMed:23920359). Forms an antiparallel dimeric structure (PubMed:17005200, PubMed:18024586, PubMed:20551331, PubMed:22178925, PubMed:23920359). Also forms dimers of homodimers (PubMed:14755055).

Also known as EMRE_ECOLI, emrE, eb, mvrC. Multidrug efflux protein that confers resistance to a wide range of toxic compounds, including ethidium, methyl viologen, acriflavine, tetraphenylphosp ...

EXTERNAL LINKS

emrE

Multidrug transporter EmrE

emrE

Molecular Synopsis