FEATURES

FAMILY

ribonucleoside diphosphate reductase large chain family

DESCRIPTION

Also known as RIR1_HUMAN, RRM1, RR1. Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B. Interacts with AHCYL1 which inhibits its activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RRM1

Ribonucleoside-diphosphate reductase large subunit

Mutations

Mutation(s) distribution

Mutations table

Search Mutation