FEATURES

FAMILY

DESCRIPTION

Also known as DPB2_YEAST, DPB2. As accessory component of the DNA polymerase epsilon complex participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair. DNA polymerase epsilon is a heterotetramer consisting of POL2, DPB2, DPB3 and DPB4.

EXTERNAL LINKS

uniprot
enzyme classification

DPB2

Mutations

Mutation(s) distribution

Mutations table