FEATURES

FAMILY

DESCRIPTION

Also known as GA45A_HUMAN, GADD45A, DDIT1, GADD45. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Interacts with MAPK14 (By similarity). Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GADD45A

Growth arrest and DNA damage-inducible protein GADD45 alpha

GADD45A

Molecular Synopsis