FEATURES

FAMILY

DESCRIPTION

Also known as CXCR2_HUMAN, CXCR2, IL8RB. Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CXCR2

C-X-C chemokine receptor type 2

Mutations

Mutation(s) distribution

Mutations table

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