FEATURES

FAMILY

class-II pyridoxal-phosphate-dependent aminotransferase family

DESCRIPTION

Also known as LCB1_YEAST, LCB1, END8, TSC2. Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine. LCB1 and LCB2 encode essential subunits of the enzyme and form a heterodimer. Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3. Interacts with LCB2 and TSC3.

Also known as LCB1_YEAST, LCB1, END8, TSC2. Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with p ...

EXTERNAL LINKS

uniprot
enzyme classification

LCB1

Serine palmitoyltransferase 1

LCB1

Structural Ligandability

Domains Chains

Distribution