FEATURES

FAMILY

DESCRIPTION

Also known as SYP1_YEAST, SYP1. Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during budding and/or cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Plays also a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle-dependent dynamics of the septin cytoskeleton by promoting septin turnover in different cell cycle stages. May act through the RHO2 signaling pathway to repolarize cortical actin patches in profilin-deficient cells. Interacts with CDC3, CDC10, CDC11, CDC12, EDE1 and EPS15.

EXTERNAL LINKS

SYP1

Mutations

Mutation(s) distribution

Mutations table