FEATURES

FAMILY

ligand-gated ion channel (TC 1.A.9) family

DESCRIPTION

Also known as GBRA2_MOUSE, Gabra2, Gabra-2. Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:27129275). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (PubMed:27129275). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed:11528422). Interacts with UBQLN1 (PubMed:11528422). Interacts with KIF21B (By similarity). Interacts with LHFPL4 (PubMed:28978485, PubMed:11528422) (By similarity). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (PubMed:31601770).

EXTERNAL LINKS

Gabra2

Gamma-aminobutyric acid receptor subunit alpha-2

Mutations

Mutation(s) distribution

Mutations table

Search Mutation