FEATURES

FAMILY

DESCRIPTION

Also known as EXE4_HELSU, EXE4. Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.

EXTERNAL LINKS

uniprot
enzyme classification

EXE4

Mutations

Mutation(s) distribution

Mutations table