FEATURES

FAMILY

DESCRIPTION

Also known as IVD_HUMAN, IVD. Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway (PubMed:7640268). To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA (PubMed:7640268). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IVD

Isovaleryl-CoA dehydrogenase, mitochondrial

IVD

Molecular Synopsis