FEATURES

FAMILY

DESCRIPTION

Also known as BLAB_AERHY, cphA. Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring (PubMed:15588826, PubMed:17307979, PubMed:1856163, PubMed:19651913, PubMed:2327760). It is able to hydrolyze penicillin and imipenem, but is much less active against cephalothin, cefotaxime, meropenem and ceftazidime (PubMed:1856163, PubMed:2327760). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

cphA

Metallo-beta-lactamase type 2

cphA

Molecular Synopsis