FEATURES

FAMILY

DESCRIPTION

Also known as AVR2A_HUMAN, ACVR2A, ACVR2. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401). Mediates induction of adipogenesis by GDF6 (By similarity). Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Interacts with type I receptor ACVR1 (PubMed:17911401). Interacts with BMP7 (PubMed:12667445).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ACVR2A

Mutations

Mutation(s) distribution

Mutations table