FEATURES

FAMILY

DESCRIPTION

Also known as DCTN1_RAT, Dctn1. Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitment to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation. Monomer and homodimer (PubMed:23648839). Dynactin is a large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE2 and MAPRE3. Interacts with FBXL5. Interacts with ECPAS and SNX6. Interacts with CLIP1. Interacts with CLN3 and DYNAP. Interacts with MISP; this interaction regulates its distribution at the cell cortex. Interacts with CEP131 (By similarity). Interacts (via CAP-Gly domain) with the C-terminus of MAPRE1, forming a heterotetramer (PubMed:23648839). Interacts with dynein intermediate chain and dynein heavy chain. Interacts with PLK1 (via POLO-box domain). Binds preferentially to tyrosinated microtubules than to detyrosinated microtubules. Interacts with TBCB, PARD6A, HPS6, KIF3A. Interacts with BICD2. Identified in a complex with MREG and RILP (By similarity). Interacts with BCCIP. Interacts with DCDC1 (By similarity). Interacts with AKNA (By similarity). Interacts with DYNC1I2 (By similarity).

EXTERNAL LINKS

Dctn1

Mutations

Mutation(s) distribution

Mutations table