FEATURES

FAMILY

DESCRIPTION

Also known as DMA_HUMAN, HLA-DMA, DMA, RING6. Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Heterodimer of an alpha chain (DMA) and a beta chain (DMB) (PubMed:16547258, PubMed:9768757). Interacts with MHCII; this interaction mediates rapid selection of high-affinity peptides in a pH-dependent manner, with an optimum at pH 5.5 (PubMed:23260142).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HLA-DMA

HLA class II histocompatibility antigen, DM alpha chain

HLA-DMA

Molecular Synopsis