FEATURES

FAMILY

DESCRIPTION

Also known as GRK1_BOVIN, GRK1, RHOK. Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:12686556, PubMed:16675451, PubMed:21299498). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). Interacts (via N-terminus) with RCVRN (via C-terminus); the interaction is Ca(2+)-dependent (PubMed:16675451, PubMed:17020884, PubMed:21299498, PubMed:24189072, PubMed:26584024). Interacts (when prenylated) with PDE6D; this promotes release from membranes (PubMed:14561760). May form a complex composed of RHO, GRK1 and RCVRN in a Ca(2+)-dependent manner; RCVRN prevents the interaction between GRK1 and RHO (PubMed:17020884).

EXTERNAL LINKS

GRK1

Rhodopsin kinase GRK1

GRK1

Molecular Synopsis