FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DHI1_HUMAN, HSD11B1, HSD11, HSD11L, SDR26C1. Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone (PubMed:10497248). Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HSD11B1

Corticosteroid 11-beta-dehydrogenase isozyme 1

HSD11B1

Molecular Synopsis