FEATURES

FAMILY

DESCRIPTION

Also known as IMPA1_HUMAN, IMPA1, IMPA. Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1, 3-diphosphate, myo-inositol 1, 4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IMPA1

Mutations

Mutation(s) distribution

Mutations table