FEATURES

FAMILY

DESCRIPTION

Also known as NOS3_BOVIN, NOS3. Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Homodimer. Interacts with NOSIP and NOSTRIN (By similarity). Interacts with HSP90AB1 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

NOS3

Nitric oxide synthase, endothelial

Mutations

Mutation(s) distribution

Mutations table

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