FEATURES

FAMILY

DESCRIPTION

Also known as ECHM_HUMAN, ECHS1. Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate. Homohexamer; dimer of trimers.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ECHS1

Enoyl-CoA hydratase, mitochondrial

ECHS1

Molecular Synopsis