FEATURES

FAMILY

DESCRIPTION

Also known as AGTR1_HUMAN, AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B. Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system., (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. Interacts with MAS1 (Probable) (PubMed:15809376). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

Also known as AGTR1_HUMAN, AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B. Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium secon ...

EXTERNAL LINKS

AGTR1

Type-1 angiotensin II receptor

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

AGTR1

Structural Ligandability

Domains Chains

Distribution