FEATURES

FAMILY

DESCRIPTION

Also known as PUR8_HUMAN, ADSL, AMPS. Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ADSL

Adenylosuccinate lyase

ADSL

Molecular Synopsis