FEATURES

FAMILY

DESCRIPTION

Also known as PUR9_CHICK, ATIC, PURH. Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:12501179). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:12501179). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity). Homodimer (PubMed:11323713, PubMed:12501179). Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (By similarity).

EXTERNAL LINKS

ATIC

Mutations

Mutation(s) distribution

Mutations table