FEATURES

FAMILY

inositol 1,4,5-trisphosphate 5-phosphatase type II family

DESCRIPTION

Also known as I5P2_HUMAN, INPP5B, OCRL2. Hydrolyzes phosphatidylinositol 4, 5-bisphosphate (PtIns(4, 5)P2) and the signaling molecule phosphatidylinositol 1, 4, 5-trisphosphate (PtIns(1, 4, 5)P3), and thereby modulates cellular signaling events. Interacts with APPL1, FAM109A and FAM109B (PubMed:20133602, PubMed:21233288). Interacts with several Rab GTPases, at least RAB1A, RAB2A, RAB5A, RAB6A, RAB8A, RAB9A and RAB33B; these interactions may play a dual role in targeting INPP5B to the specific membranes and stimulating its phosphatase activity (PubMed:17956944, PubMed:26824392, Ref.12). Interacts preferentially with non-phosphorylated RAB8A; phosphoryation of RAB8A on 'Thr-72' disrupts this interaction (PubMed:26824392). Interacts with INPP5F (PubMed:25869668).

EXTERNAL LINKS

INPP5B

Mutations

Mutation(s) distribution

Mutations table