FEATURES

FAMILY

DESCRIPTION

Also known as IRE1_YEAST, IRE1, ERN1. Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Homodimer; in response to the accumulation of unfolded proteins.

EXTERNAL LINKS

uniprot
enzyme classification

IRE1

Serine/threonine-protein kinase/endoribonuclease IRE1

IRE1

Molecular Synopsis