FEATURES

DESCRIPTION

Also known as RAD23_YEAST, RAD23. Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Interacts directly with PNG1.

EXTERNAL LINKS

uniprot
enzyme classification

RAD23

Mutations

Mutation(s) distribution

Mutations table