FEATURES

DESCRIPTION

Also known as NTF2_YEAST, NTF2. Facilitates protein transport into the nucleus. Interacts with various nucleoporins and with Ran-GDP. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import. In vitro, the NTF2-Ran-GDP association, in the presence of GTP, triggers dissociation of the karyopherin alpha-beta complex, allowing nuclear translocation of karyopherin alpha and the NLS substrate.

EXTERNAL LINKS

uniprot
enzyme classification

NTF2

Nuclear transport factor 2

Mutations

Mutation(s) distribution

Mutations table

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